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Real members of DiabetesTeam have posted questions and answers that support our community guidelines, and should not be taken as medical advice. Looking for the latest medically reviewed content by doctors and experts? Visit our resource section.
A DiabetesTeam Member asked a question 💭
Binghamton, NY

My doctor just increased my ozempic and metformin. I took it earlier and it upset my stomach. What can I do to help my meds from upsetting my stomach?

2 days ago (edited)
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DiabetesTeam

Starting Ozempic and metformin together can definitely cause some stomach upset — so first off, hang in there! Stomach issues are very common when beginning these medications and often improve as the body adjusts.

Here are some tips that may help:

- Take metformin with food — always take it with a meal, ideally the last Show Full Answer

Starting Ozempic and metformin together can definitely cause some stomach upset — so first off, hang in there! Stomach issues are very common when beginning these medications and often improve as the body adjusts.

Here are some tips that may help:

- Take metformin with food — always take it with a meal, ideally the last meal of the day, to reduce stomach irritation
- Ask about extended-release metformin — this version is often much easier on the stomach than the regular tablet
- Stay well hydrated — drink plenty of water throughout the day
- Eat smaller meals — large meals can make nausea worse, especially with Ozempic
- Avoid fatty or spicy foods — these can aggravate nausea when starting these medications
- Take it slow — Ozempic is typically started at a low dose and gradually increased to help the body adjust If the stomach upset continues or becomes severe — especially if there's significant abdominal pain, vomiting, or trouble keeping food down — it's worth reaching out to the doctor right away. They may be able to adjust the dosing schedule or switch to the extended-release version of metformin to make things more comfortable.

2 days ago
A DiabetesTeam Member

Unfortunately, all meds have side effects. An increase in your dosage will cause tummy issues until your body adjusts to it. I'm sorry you are experiencing this. Hopefully things will work out and you will feel better soon.

2 days ago (edited)
A DiabetesTeam Member

Yes, you can take all of the anti-diabetic meds with food (at least the oral ones)

The only type with any kind of food association is Sulfonylurea class drugs (names end in IDE, like Glimeperide or Glyburide etc) which are Only taken before eating because without food they could kill you due to low blood sugar

It does NOT matter what time of day you take your Metformin as long as you don't forget. Before bed or first thing in the morning is used to help you form a habit

But in the case of Metformin, it takes between 2 and 8 hours to get into your system and it stays there for about 48 hours. So each time you take a dose you are "adding to" some amount already floating around doing it's thing

If you take it immediately before eating, the food can help it quickly pass through the gut into the small intestine before it really starts dissolving seriously and it's usually the stomach that is irritated by it

2 days ago (edited)
A DiabetesTeam Member

Water! Water! Water! Start with a small dose with the Ozempic I have been told.
Try any drug like Metformin with food. I usually take with breakfast in the morning and my last meal of the day. Slow and steady is my motto.
Are you taking the meds at the same time? If it were me, I wouldn’t just because that might be asking for it!

2 days ago (edited)
A DiabetesTeam Member

Can you take RX (meds) with food ?

2 days ago

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