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Real members of DiabetesTeam have posted questions and answers that support our community guidelines, and should not be taken as medical advice. Looking for the latest medically reviewed content by doctors and experts? Visit our resource section.

Diabetic Medication Side Effects

A DiabetesTeam Member asked a question 💭
San Jose, CA

Question: has anyone taken Metformin and Glipizide, together, and had side effects? I'm talking about digestive issues; such as heart burn or acid reflux? I've researched Metformin and it said that users can experience such symptoms after taking Metformin for several years. I've been taking it for 6 1/2 years. When I last saw my end, she doubled the dosage for Glipizide, wanting to get my blood sugar lower. I think it's working but in the last six weeks, I've had acid reflux, after eating. I've… read more

March 6
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A DiabetesTeam Member

That's alarming, Mary780! What were you prescribed in it's place?

March 7
A DiabetesTeam Member

I had to stop taking metformin because of severe digestive issue....
That was several years ago and my stomach has never fully been right

March 6
DiabetesTeam

Are you experiencing digestive issues like heartburn or acid reflux after your Glipizide dosage was doubled?

Digestive issues are a known side effect of metformin, and they can include nausea, diarrhea, and upset stomach. While metformin is often the culprit for these symptoms, the timing of your acid reflux starting right Show Full Answer

Are you experiencing digestive issues like heartburn or acid reflux after your Glipizide dosage was doubled?

Digestive issues are a known side effect of metformin, and they can include nausea, diarrhea, and upset stomach. While metformin is often the culprit for these symptoms, the timing of your acid reflux starting right after your Glipizide dose increased is worth noting.

Since you've been on metformin for 6½ years and only recently developed reflux after the Glipizide change, it's possible the higher dose is contributing to your symptoms. However, metformin can also cause digestive issues that develop or worsen over time. Here are some suggestions that might help:

* Talk to your doctor about switching to extended-release metformin if you're not already taking it. Many people find it easier to tolerate and it causes fewer digestive problems.

* Ask your doctor if your Glipizide dose can be adjusted or if there's an alternative medication that might work better for you.

* Keep track of when your symptoms occur - is it after certain meals or at specific times of day? This information can help your doctor figure out what's going on.

* Stay hydrated and eat smaller, more frequent meals rather than large ones, which can sometimes help with reflux.

Don't try to adjust your medications on your own. Your healthcare provider can review your treatment plan and help you find the right balance between controlling your blood sugar and managing side effects.

March 6

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