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Medication
A DiabetesTeam Member asked a question πŸ’­

Hi everyone

Just wondering if anyone has feedback about janumet XR. My last fasting was 7.2 A1C 6.6. My former physician had me on 2000 mg of metformin and not concerned.
The new physician concerned and put me on janumet XR. I have read about it and concerned .
Any feedback would be helpful

posted October 31, 2021
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A DiabetesTeam Member

Honestly not really I have never had issues with metformin just the fact I am on something new. Thanks for asking and all your knowledge you are sharing πŸ˜€

posted November 4, 2021
A DiabetesTeam Member

What exactly are your concerns?

It is a combination "extended release" drug that contains the metformin (same as you were taking) and Januvia, a DPP-4 class drug.

The Metformin tries to regulate how much sugar your liver puts out to improve your fasting numbers.

The Januvia tries to block the signal sent "after you have finished digesting a meal" that tells the Pancreas to stop releasing insulin. If that is effective you produce a little more insulin (yourself) then what you need to deal with the meal, so that extra insulin can deal with the "leftover" blood sugars - so your post meal, between meal and random blood sugars should be lower.

If you are simply concerned because you googled the drug and saw the phonebook length of noted side effects then don't ever check Tylenol πŸ˜ƒ

Metformin has been prescribed, at least in the UK for over 80 years (50 in Canada) and if it was even "remotely dangerous" it would be well known by now.

The Januvia is one of the oldest of the "newer drugs" - it simply tries to stop your system from releasing a hormone (it's an "inhibitor") so it's stopping something not forcing your system to do something, which makes it inherently more safe at least as far as "action of medication" is concerned compared to many drugs.

The bottom line is, both medications (substances) are "foreign" to your system. Any time you introduce something that "isn't there naturally" you run the risk of an adverse reaction. So you and your Doc have to weigh the benefits against the dangers.

Uncontrolled blood sugar WILL "mess you up badly leading to death" - so you have to balance that off against the very very low odds of you having some kind of reaction to the drugs.

posted November 4, 2021

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